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KMID : 0352720130370010074
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Journal of Ginseng Research
2013 Volume.37 No. 1 p.74 ~ p.79
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Oleanane-triterpenoids from Panax stipuleanatus inhibit NF-κB
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Chun Liang
Yan Ding
Song Seok-Bean
Kim Jeong-Ah
Nguyen Manh Cuong
Ma Jin-Yeul
Kim Young-Ho
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Abstract
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In continuation of our research to find biological components from Panax stipuleanatus, four oleanane-type triterpenes (12 to 15) were isolated successively. Fifteen oleanane-type saponins (1 to 15) were evaluated for nuclear factor (NF)-κB activity using a luciferase reporter gene assay in HepG2 cells. Compounds 6 to 11 inhibited NF-κB, with IC50 values between 3.1 to 18.9 μM. The effects on inducible nitric oxide synthase and cyclooxygenase-2 by compounds 8, 10, and 11 were also examined using reverse transcription-polymerase chain reaction. Three compounds (8, 10, and 11) inhibited NF-κB activity by reducing the concentration of inflammatory factors in HepG2 cells.
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KEYWORD
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Panax ginseng, Panax stipuleanatus, Oleanane-type triterpenoid, Nuclear factor-κB
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